- Interesting observations that turn widely-accepted concepts of "normal grief" on its head: http://bit.ly/5y0yg9 (via @TheSofa) #
- Use those holiday gift cards NOW! NYT article re: how not to postpone pleasure – http://bit.ly/7MKAFM (via @TheSofa) #
- National Institute on Drug Abuse has a site just for teens – start at the blog: http://teens.drugabuse.gov/blog/ (via @thinkshrink) #
- Bench to bedside may not be for a while, but fascinating research re: panic attacks: http://bit.ly/8bPgWU (via @hrana) #
- Just added myself to the http://wefollow.com twitter directory under: #san_mateo_ca #psychiatry #psychiatrist #psychology #psychotherapist #
Monthly Archive for December, 2009
- Being a victim of airborne terrorism is less likely than being struck by lightning, but remains scary nonetheless: http://bit.ly/7iD8Cl #
- Fascinating! RT @hrana News: The operation to 'cure' high blood pressure: how it works http://bit.ly/8rBEom #health #medicine #
- RT @cnnbrk Fresh clashes break out between police and protesters in Iran. http://bit.ly/5EERNl #
Attention Deficit Hyperactivity Disorder (ADHD) is a disorder that is both common and controversial. Its controversy likely stems from the fact that it is one of the most commonly diagnosed mental disorders in children, and treatment often involves prescribing stimulants, which are controlled substances. This article will be focused on ADHD in adults.
Introduction
It is estimated that in any given year, ADHD affects 4.1 percent of adults, ages 18-44. Although everyone has occasional lapses in attention and concentration, people with ADHD have symptoms that significantly affects their ability to function in school, work, home, and social settings.
Symptoms:
ADHD in adults can be conceptualize as a disorder of our brain’s “executive functions”. The executive functions include planning, initiating and inhibiting actions, selecting relevant sensory information to focus on, etc. Impairment of the executive functions can result in many of the following symptoms:
Inattentiveness as displayed in:
-Difficulty paying attention to details, or careless mistakes in schoolwork, work, or other activities.
-Difficulty keeping attention on tasks or activities
-Difficulty following instructions on tasks despite understanding instructions
-Difficulty focusing on the current conversation because of distracting background noises or conversations
-Difficulty organizing activities
-Difficulty focusing on tasks for a long period of time
-Often misplacing or losing belongings
-Often easily distracted
-Often forgetful in daily activities
Hyperactivity as displayed in:
-Often feeling fidgety during meetings, resulting in fidgeting with hands or feet, shifting positions in seat, or standing up from seat when remaining in the seat is expected.
-Often feeling restless, feeling “driven by a motor”, or always “on the go”
-Often talking excessively
Impulsivity as displayed in:
-Often blurting out answers before questions have been finished, interrupting others as they are speaking, or intruding on others’ conversations
-Difficulty waiting one’s turn
Diagnosis
Diagnosis of ADHD in an adult is dependent on a history of ADHD symptoms in childhood before age 7. If ADHD-like symptoms suddenly emerge in adulthood without a childhood history, it is likely that a different disorder with overlapping symptoms is responsible. Major depression and bipolar disorder, among others, can mimic different aspects of ADHD.
There must also be clear evidence of significant impairment of functioning from ADHD symptoms in more than one realm (e.g. home, school, work and social settings).
There are three major types of ADHD:
1.ADHD Predominantly Inattentive Type: formerly known as “Attention Deficit Disorder”, or ADD.
2.ADHD, Predominantly Hyperactive-Impulsive Type
3.ADHD, Combined Type: ADHD combined type is a combination of the symptoms of inattentive type and hyperactive-impulsive type.
Of note, many still use the term “Attention Deficit Disorder” or “ADD” to refer to ADHD – Inattentive Type. This is because the term “ADD” was used until 1987 when it was changed to ADHD – Inattentive Type with the DSM-III-R.
ADHD is diagnosed clinically, based on history. Oftentimes, information from parents or teachers is helpful. Psychological testing is sometimes used to help diagnose unclear cases of ADHD. There is no blood test or imaging test that is diagnostic for ADHD. However, if there are clinical signs that suggest a medical problem may be contributing to ADHD symptoms, your doctor may order blood tests or brain imaging tests to see if there are any other factors contributing to the ADHD symptoms.
Treatment
Treatment can involve therapy, medications, or combined treatment, depending on patient preference and severity of symptoms.
- Therapy: Behavior therapy has been shown to be effective in children with ADHD. In adults, elements of cognitive behavioral therapy (CBT) and cognitive rehabilitation including compensatory strategies can be helpful to cope more effectively with the disorder.
- Medications: The most commonly used medications for treating ADHD are stimulants. These medications are controlled substances and are generally prescribed by a psychiatrist or neurologist. There are two major classes of stimulants: amphetamine class stimulants and methylphenidate class stimulants. There are also other types of ADHD medications that do not fall into the amphetamine or methylphenidate classes. Click the links below for more information on the different types of ADHD medications:
- Combined Treatment: The combination of therapy and medications can be the most effective form of treatment for some patients.
Treatment with stimulants needs to be carefully monitored. Your physician will need to know about any personal or family history of cardiac problems including heart attacks, high blood pressure, arrthymias, etc. You may need to undergo an electrocardiogram (EKG) or further testing prior to initiating treatment if there is the possibility of cardiac problems. Your physician will want to monitor your blood pressure and heart rate periodically, as those can be increased by stimulants. Common side effects that will also need to be monitored is possible weight loss because of appetite suppression, and slowed growth in children.
For Further Information
See the Wikipedia entry on ADHD, or contact a qualified mental health professional.
Article written 12/19/09 by Minyang Mao, M.D.
Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.
Content © 2009 Minyang Mao, M.D. Image © 2009 Bob Lin. All rights reserved.
- New blog article: "Attention Deficit Hyperactivity Disorder (ADHD / ADD)" http://minyangmaomd.com/adhd/ #
Mechanism of Action:
Whereas medications in the methylphenidate and amphetamine classes all act by increasing the release of norepinephrine and dopamine and blocking their reuptake, the following ADHD medications act in different ways.
Other ADHD Medications:
Bupropion (generic) – Inhibits norepinephrine and dopamine reuptake. Also used as an antidepressant and smoking cessation aid. Available as generic or as brand-name Wellbutrin.
Strattera (atomoxetine) – Inhibits norepinephrine reuptake. Unique in that it does not become therapeutic until 4-8 weeks after initiation.
Intuniv (guanfacine) – Stimulates alpha2-adrenergic receptors. Not to be confused with guaifenesin (an over the counter cough medicine).
Provigil (modafinil) – exact mechanism of action unknown, but affects the dopamine system. Used in the military to prolong alertness. Not officially FDA approved for the treatment of ADHD, but at times prescribed “off-label”.
Article written 12/19/09 by Minyang Mao, M.D.
Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.
Content © 2009 Minyang Mao, M.D. All rights reserved.
Mechanism of Action:
Amphetamines act by increasing the release of norepinephrine and dopamine and blocking their reuptake.
Amphetamine Class Stimulants:
Dextroamphetamine (generic) – Duration 3-5 hours for immediate release version, duration 4-8 hours for extended release version
Dexedrine (dextroamphetamine) – Discontinued in the U.S.
Procentra (dextroamphetamine) – Duration 3-5 hours
Amphetamine/Dextroamphetamine (generic) – Duration 3-5 hours for immediate release version, duration 4-8 hours for extended release version
Adderall (amphetamine/dextroamphetamine) – Duration 3-5 hours
Adderall XR (amphetamine/dextroamphetamine) – Duration 8-12 hours
Vyvanse (lisdexamfetamine) – a pro-drug that is converted to dextroamphetamine by the liver, duration 9-13 hours
Article written 12/19/09 by Minyang Mao, M.D.
Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.
Content © 2009 Minyang Mao, M.D. All rights reserved.
Mechanism of Action:
Methylphenidate class stimulants act by increasing the release of norepinephrine and dopamine and blocking their reuptake.
Methylphenidate Class Stimulants:
Methylphenidate (generic) – Duration 3-5 hours for immediate release version, duration 4-8 hours for extended release version
Ritalin (methylphenidate) – Duration 3-5 hours
Ritalin SR (methylphenidate) – Duration 4-8 hours
Ritalin LA (methylphenidate) – Duration 8-12 hours
Methylin (methylphenidate) – Duration 3-5 hours
Methylin ER (methylphenidate) – Duration 4-8 hours
Metadate ER (methylphenidate) – Duration 4-8 hours
Metadate CD (methylphenidate) – Duration 8-12 hours
Concerta (methylphenidate) – Duration 8-12 hours
Daytrana (methylphenidate transdermal) – Duration 2 hours after application until up to 5 hours after removal
Focalin (dexmethylphenidate) – Duration 3-5 hours
Focalin XR (dexmethylphenidate) – Duration 8-12 hours
Article written 12/19/09 by Minyang Mao, M.D.
Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.
Content © 2009 Minyang Mao, M.D. All rights reserved.
Depression is an extremely common problem that many people struggle with. I hope that this article will be helpful and educational.
Introduction
It is estimated that in any given year, 6.7 percent of the U.S. population has Major Depressive Disorder (MDD), the clinical name for what people generally refer to as depression. A medication used to treat depression is the third most prescribed medication in the U.S., behind only cholesterol-lowering medication and asthma medication. Although everyone has ups and downs in their moods, people with MDD have such severe downs that it significantly affects their daily function.
Symptoms
The main symptom of MDD is depressed mood, plus additional common symptoms as described by the mnemonic SIGECAPS:
S: Sleep (decreased or increased)
I: Interest (decreased, also known as anhedonia)
G: Guilt (feeling worthless, hopeless, helpless)
E: Energy (decreased)
C: Concentration (decreased)
A: Appetite (decreased or increased)
P: Psychomotor retardation or activation (feeling slowed or feeling restless)
S: Suicidal thoughts
Diagnosis
As with most mood disorders, MDD is diagnosed clinically, based on history. There is no blood test or imaging test that is diagnostic for MDD. However, if there are clinical signs that suggest a medical problem may be contributing to your depression, your doctor may order blood tests to check for infections and check your thyroid, liver, kidneys, and vitamin B12 and folate levels to see if there are any other factors contributing to your depression. At times, brain imaging may be helpful to make sure there are not any underlying brain abnormalities that are contributing to your depression. Before initiating medication treatment of MDD, it is important that your doctor screen you for Bipolar Affective Disorder (BPAD), as many anti-depressant medications that can help people with MDD can actually make people with BPAD much more unstable.
Treatment
Treatment can involve psychotherapy, medications, or combined treatment, depending on patient preference and severity of symptoms.
- Psychotherapy: Cognitive Behavioral Therapy (CBT) has been shown to be effective for Major Depressive Disorder. I recommend a CBT workbook to my depressed patients - The Feeling Good Handbook by David D. Burns. Many patients find it helpful to go through the workbook and suggested exercises with the guidance of a mental health professional, though the workbook is made to be self-guided. Some patients find insight-oriented psychotherapy or supportive therapy to be more helpful types of therapy than CBT.
- Medications: The most commonly used medications for treating Major Depressive Disorder are selective serotonin reuptake inhibitors (SSRI’s). These medications can be prescribed by your primary care doctor, or by your psychiatrist. If SSRI’s are not effective, serotoinin-norepinephrine reuptake inhibitors (SNRI’s), other anti-depressants such as bupropion (Wellbutrin), atypical antipsychotics, and other adjunctive medications can be effective. Older medications such as monoamine oxidase inhibitors (MAOI’s) and tricyclic antidepressants (TCA’s) can also be alternatives if newer, safer medications are not effective. The best predictor of your response to medications is how you have responded to medications in the past. How blood-relatives have responded to medications in the past can also help your doctor choose the best medication for you.
- Combined Treatment: For many patients, the combination of psychotherapy and medications is the most effective form of treatment.
For Further Information
See the Wikipedia entry on MDD, a handout from the National Institute for Mental Health (NIMH), or contact a qualified mental health professional.
Article written 12/1/09 by Minyang Mao, M.D. Revised 12/1/09 by Minyang Mao, M.D.
Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.
Content © 2009 Minyang Mao, M.D. Image © 2009 Bob Lin. All rights reserved.
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