Other ADHD Medications

Mechanism of Action:

Whereas medications in the methylphenidate and amphetamine classes all act by increasing the release of norepinephrine and dopamine and blocking their reuptake, the following ADHD medications act in different ways.

Other ADHD Medications:

Bupropion (generic) – Inhibits norepinephrine and dopamine reuptake.  Also used as an antidepressant and smoking cessation aid.  Available as generic or as brand-name Wellbutrin.

Strattera (atomoxetine) – Inhibits norepinephrine reuptake. Unique in that it does not become therapeutic until 4-8 weeks after initiation.

Intuniv (guanfacine) – Stimulates alpha2-adrenergic receptors.  Not to be confused with guaifenesin (an over the counter cough medicine).

Provigil (modafinil) – exact mechanism of action unknown, but affects the dopamine system.  Used in the military to prolong alertness.  Not officially FDA approved for the treatment of ADHD, but at times prescribed “off-label”.

Article written 12/19/09 by Minyang Mao, M.D.

Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.

Content © 2009 Minyang Mao, M.D.  All rights reserved.

Amphetamine Class Stimulants

Mechanism of Action:

Amphetamines act by increasing the release of norepinephrine and dopamine and blocking their reuptake.

Amphetamine Class Stimulants:

Dextroamphetamine (generic) – Duration 3-5 hours for immediate release version, duration 4-8 hours for extended release version

Dexedrine (dextroamphetamine) – Discontinued in the U.S.

Procentra (dextroamphetamine) – Duration 3-5 hours

Amphetamine/Dextroamphetamine (generic) – Duration 3-5 hours for immediate release version, duration 4-8 hours for extended release version

Adderall (amphetamine/dextroamphetamine) – Duration 3-5 hours

Adderall XR (amphetamine/dextroamphetamine) – Duration 8-12 hours

Vyvanse (lisdexamfetamine) – a pro-drug that is converted to dextroamphetamine by the liver, duration 9-13 hours

Article written 12/19/09 by Minyang Mao, M.D.

Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.

Content © 2009 Minyang Mao, M.D.  All rights reserved.

Methylphenidate Class Stimulants

Mechanism of Action:

Methylphenidate class stimulants act by increasing the release of norepinephrine and dopamine and blocking their reuptake.

Methylphenidate Class Stimulants:

Methylphenidate (generic) – Duration 3-5 hours for immediate release version, duration 4-8 hours for extended release version

Ritalin (methylphenidate) – Duration 3-5 hours

Ritalin SR (methylphenidate) – Duration 4-8 hours

Ritalin LA (methylphenidate) – Duration 8-12 hours

Methylin (methylphenidate) – Duration 3-5 hours

Methylin ER (methylphenidate) – Duration 4-8 hours

Metadate ER (methylphenidate) – Duration 4-8 hours

Metadate CD (methylphenidate) – Duration 8-12 hours

Concerta (methylphenidate) – Duration 8-12 hours

Daytrana (methylphenidate transdermal) – Duration 2 hours after application until up to 5 hours after removal

Focalin (dexmethylphenidate) – Duration 3-5 hours

Focalin XR (dexmethylphenidate) – Duration 8-12 hours

Article written 12/19/09 by Minyang Mao, M.D.

Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.

Content © 2009 Minyang Mao, M.D.  All rights reserved.

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Depression

Depression is an extremely common problem that many people struggle with.  I hope that this article will be helpful and educational.

Introduction

It is estimated that in any given year, 6.7 percent of the U.S. population has Major Depressive Disorder (MDD), the clinical name for what people generally refer to as depression.  A medication used to treat depression is the third most prescribed medication in the U.S., behind only cholesterol-lowering medication and asthma medication.  Although everyone has ups and downs in their moods, people with MDD have such severe downs that it significantly affects their daily function.

Symptoms

The main symptom of MDD is depressed mood, plus additional common symptoms as described by the mnemonic SIGECAPS:

S: Sleep (decreased or increased)
I: Interest (decreased, also known as anhedonia)
G: Guilt (feeling worthless, hopeless, helpless)
E: Energy (decreased)
C: Concentration (decreased)
A: Appetite (decreased or increased)
P: Psychomotor retardation or activation (feeling slowed or feeling restless)
S: Suicidal thoughts

Diagnosis

As with most mood disorders, MDD is diagnosed clinically, based on history.  There is no blood test or imaging test that is diagnostic for MDD.  However, if there are clinical signs that suggest a medical problem may be contributing to your depression, your doctor may order blood tests to check for infections and check your thyroid, liver, kidneys, and vitamin B12 and folate levels to see if there are any other factors contributing to your depression.  At times, brain imaging may be helpful to make sure there are not any underlying brain abnormalities that are contributing to your depression.  Before initiating medication treatment of MDD, it is important that your doctor screen you for Bipolar Affective Disorder (BPAD), as many anti-depressant medications that can help people with MDD can actually make people with BPAD much more unstable.

Treatment

Treatment can involve psychotherapy, medications, or combined treatment, depending on patient preference and severity of symptoms.

  • Psychotherapy: Cognitive Behavioral Therapy (CBT) has been shown to be effective for Major Depressive Disorder. I recommend a CBT workbook to my depressed patients -  The Feeling Good Handbook by David D. Burns.   Many patients find it helpful to go through the workbook and suggested exercises with the guidance of a mental health professional, though the workbook is made to be self-guided.  Some patients find insight-oriented psychotherapy or supportive therapy to be more helpful types of therapy than CBT.
  • Medications: The most commonly used medications for treating Major Depressive Disorder are selective serotonin reuptake inhibitors (SSRI’s).  These medications can be prescribed by your primary care doctor, or by your psychiatrist.  If SSRI’s are not effective, serotoinin-norepinephrine reuptake inhibitors (SNRI’s), other anti-depressants such as bupropion (Wellbutrin), atypical antipsychotics, and other adjunctive medications can be effective.  Older medications such as monoamine oxidase inhibitors (MAOI’s) and tricyclic antidepressants (TCA’s) can also be alternatives if newer, safer medications are not effective.  The best predictor of your response to medications is how you have responded to medications in the past.   How blood-relatives have  responded to medications in the past can also help your doctor choose the best medication for you.
  • Combined Treatment: For many patients, the combination of psychotherapy and medications is the most effective form of treatment.

For Further Information

See the Wikipedia entry on MDD, a handout from the National Institute for Mental Health (NIMH), or contact a qualified mental health professional.

Article written 12/1/09 by Minyang Mao, M.D.  Revised 12/1/09 by Minyang Mao, M.D.

Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.

Content © 2009 Minyang Mao, M.D.  Image © 2009 Bob Lin.  All rights reserved.

Seasonal Affective Disorder

Seasonal Affective Disorder-1It’s that time of the year again when sunlight hours get short and Seasonal Affective Disorder starts to rear its ugly head.   I hope this article will be timely and helpful.

Introduction

Seasonal Affective Disorder, or SAD, is a mood disorder related to the shortening of sunlight hours during winter.  It is more common in northern latitudes, in Finland for example.  It is difficult to have an accurate estimate of actual prevalence in the U.S., but estimates range from 0 to 9.7%.

Symptoms

Symptoms of SAD are the same as those of depression, with the main symptom of depressed mood, plus additional common symptoms as described by the mnemonic SIGECAPS:

S: Sleep (decreased or increased)
I: Interest (decreased, also known as anhedonia)
G: Guilt (feeling worthless, hopeless, helpless)
E: Energy (decreased)
C: Concentration (decreased)
A: Appetite (decreased or increased)
P: Psychomotor retardation or activation (feeling slowed or feeling restless)
S: Suicidal thoughts

The unique aspect of SAD versus non-seasonal depression is that SAD regularly appears in the fall or winter, and SAD tends to disappear during spring and summer months, whereas non-seasonal depression has no correlation to the changing of seasons.

Diagnosis

There is not currently a distinct diagnosis of “Seasonal Affective Disorder” in the DSM-IV.  Psychiatrists diagnose SAD by adding a “Seasonal Pattern Specifier” to a Major Depressive Episode that appears as part of Major Depressive Disorder or Bipolar Type I or Type II Disorder.  As with most mood disorders, SAD is diagnosed clinically, based on history.  There is no blood test or imaging test that is diagnostic for SAD.

Treatment

Treatment can involve psychotherapy, medications, light therapy, or combined treatment, depending on patient preference and severity of symptoms.

  • Psychotherapy: Cognitive Behavioral Therapy (CBT) has been shown to be effective for Seasonal Affective Disorder.  Because SAD is a subtype of depression, I recommend the same workbook to my SAD patients that I recommend for my depressed patients -  The Feeling Good Handbook by David D. Burns.   Many patients find it helpful to go through the workbook and suggested exercises with the guidance of a mental health professional, though the workbook is made to be self-guided.
  • Medications: The most commonly used medications for treating Seasonal Affective Disorder are the same medications for non-seasonal depression: selective serotonin reuptake inhibitors (SSRI’s).  These medications can be prescribed by your primary care doctor, or by your psychiatrist.
  • Light Therapy: Because the cause of Seasonal Affective Disorder appears related to the lack of sunlight exposure during fall/winter months, light therapy treatments have been developed.  Most studies have focused on 10,000 lux light therapy for 30 minutes per day, given early in the morning.  There are commercially available lightboxes and light visors that deliver this light in various forms.  The key factors for effectiveness are intensity (lux) and duration.  It is important to keep in mind that as you get farther from the light, the lux drops significantly.  Most lightboxes require that you are within 12 inches of the light to deliver the recommended 10,000 lux.  Important safety considerations are to make sure that you are not being exposed to UV light which can predispose you to skin cancer.  Some boxes use special UV-free bulbs, others use a UV light filter to screen out UV rays.  There is investigation into whether blue-light can be more effective than full-spectrum light.  Another safety issue is that light therapy can cause patients with Bipolar Disorder to become manic or hypomanic.  Thus, I recommend that light therapy be initiated and conducted under the supervision of a psychiatrist.
  • Combined Treatment: For some patients, the combination of psychotherapy, medications, and light therapy is the most effective form of treatment.

For Further Information

See the Wikipedia entry on SAD, a Mayo Clinic article on SAD, an article from the American Academy of Family Physicians, or contact a qualified mental health professional.

Article written 11/10/09 by Minyang Mao, M.D.  Revised 11/10/09 by Minyang Mao, M.D.

Disclaimer: This article is intended as an educational resource only, and is not intended to be a replacement for treatment. For evaluation and treatment, please contact a qualified mental health professional.

Content © 2009 Minyang Mao, M.D.  Image © 2009 Bob Lin.  All rights reserved.

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Fourth Teen Suicide in Six Months at Gunn High in Palo Alto

Saw heartbreaking news today: the string of suicides at Gunn High in Palo Alto continues, with the latest this past Monday.  Local news reports on it here: http://MinyangMaoMD.com/u/ueum5jnm

My previous blog post on this topic is here: http://MinyangMaoMD.com/teen-suicide

A forum was held at Gunn High last night to discuss what to do about this very concerning “cluster” of suicides.   Local news reports on the forum here: http://MinyangMaoMD.com/u/4px3nuux

I will be looking into how I can get involved to help in this crisis.  More on this later.   Please keep Gunn High, the students, and the victims’ parents, families, and friends in your prayers.

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  • Medscape is Pharma funded – will have to be extra critical in reading their "CME". Thanks @dcarlat – keep it up! http://bit.ly/cxR9A #
  • RT @thinkshrink: Psych Central interview with Dr. Dan Carlat from last summer-http://bit.ly/cxR9A #